Journal article
Blood pressure modifies retinal susceptibility to intraocular pressure elevation
Z He, CTO Nguyen, JA Armitage, AJ Vingrys, BV Bui
Plos One | Published : 2012
Abstract
Primary open angle glaucoma affects more than 67 million people. Elevated intraocular pressure (IOP) is a risk factor for glaucoma and may reduce nutrient availability by decreasing ocular perfusion pressure (OPP). An interaction between arterial blood pressure and IOP determines OPP; but the exact contribution that these factors have for retinal function is not fully understood. Here we sought to determine how acute modifications of arterial pressure will affect the susceptibility of neuronal function and blood flow to IOP challenge. Anaesthetized (ketamine:xylazine) Long-Evan rats with low (~60 mmHg, sodium nitroprusside infusion), moderate (~100 mmHg, saline), or high levels (~160 mmHg, a..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study received funding support from the National Health and Medical Research Council (NHMRC grant 566570) of Australia and the Albert Shimmins Memorial Fund. JAA is a Monash Fellow and was supported by a National Heart Foundation Postgraduate Fellowship during the course of these studies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.